Posted in Podcast, Pharmacology Episodes

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In this episode, I’m breaking down the concept of first-pass metabolism, also known as the first-pass effect, and why it’s important for nurses to understand. You’ll learn how medications are metabolized, why bioavailability matters, and how the first-pass effect impacts drug dosing and effectiveness. We also discuss common medications affected by this process and how it influences the choice of administration routes.

Listen to this episode and you’ll learn:

  • What the first-pass effect is – Get a brief overview of how PO medications are metabolized in the liver before reaching systemic circulation
  • The basics of bioavailability – Learn how bioavailability measures how much of a drug reaches systemic circulation and why IV medications have higher bioavailability than oral medications.
  • Some common medications affected by first-pass metabolism – Bring this concept to life with medication examples including nitroglycerine and diazepam.
  • Nursing implications – Discover how understanding first-pass effect helps nurses administer medications effectively and why it impacts the timing of a drug’s onset of action.

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Full Transcript – Read the article and view references

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Last Updated on December 12, 2024 by Maureen Osuna, MSN, RN