Epidermal necrolysis refers to severe cutaneous reactions that cause extensive necrosis of tissue and detachment of the epidermis. It encompasses three conditions which are on a continuum of severity and how much of the body’s surface area is affected:

  • Stevens-Johnson syndrome (SJS): Less than 10% of BSA is detached
  • Toxic epidermal necrolysis (TEN) – More than 30% of BSA is detached
  • SJS/TEN overlap: Between 10 and 30% of BSA is detached

In this episode you’ll learn: 

  • Epidermal necrolysis pathophysiology and risk factors
  • High risk medications that can cause SJS/TEN
  • Complications of SJS/TEN
  • Signs and symptoms in the prodromal and acute phase
  • Important assessment for a patient with SJS/TEN
  • Key tests utilized to diagnose and evaluate a patient with epidermal necrolysis
  • Treatments for SJS/TEN, including medications
  • Vital education components for patients and families

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